In this paper, we propose an optimization method to suitable locating minimum number of transmitter antennas to provide adequately signal coverage in a given indoor environment. This method is based on an integrated realized Ray-Tracing (RT) technique, so-called Ray-Tracing Engine (RTE), and Genetic Algorithm (GA). This integration provides an intelligent system in optimization process. To provide freedom in furniture placement each corner of every room contains a receiver. Therefore, we have a dense map of RSS distribution in propagation environment. According to Simulation results a full coverage using integrated RTE and GA is achieved through suitably locating three transmitters. Furthermore, GA avoids the time consuming process of antenna location finding in an exhaustive search method.